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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21126456c07d6a99aa03641d451c1e354d7fa4c8732f32baec1dcca6fe496cb1' 
  AND token = '/k8Eod3WWhNz38m6VdsNJknULUYoPorqSRA1rXFojus=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}