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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a5228a364d9a76a64189a430b6838c9cecce6fe6e1d65653ea0e02e072da304' 
  AND token = '6OWoxDUT4lcx/fWzfT6p3yv6XD24AvBq5nuTELReZkM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}