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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22043a2f1c67fa66ec554732610d36e32297acb7db8c58222b04ecb2c4f7a7b1' 
  AND token = '/l2+1DD29X8SK1QtBqml9E5mZQYVKRZGoFj4Fah119A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}