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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43f1ff91e27d2c865773922b7fd13703288e534779268c6c6678b255e25b1e34' 
  AND token = 'cx2/R7BCy1QWFBBqi/qPOltTYU2lYPiIhtLORS9dWIQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}