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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '375ec00905fe28ec0c184b65803c877c3e1f138d16ebe78c9cc9a648e7e2eff6' 
  AND token = 'JhmWYCevyHhGeLdO84haFo6GqB5+hiWkgqxKRdY4FPo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00052

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}