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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78c600d49e90dc44a3ab86dcebd1ab377987acc49e57dfcfc2c38b929e4014ca' 
  AND token = '23ketqnQkBIR299GCJfKTNFMgGF2GtHFikBJk+W/GXc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}