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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49fb63b1e6e812b6521afb92f52df72ff1acccea5142f3f6b828dce3c3c65020' 
  AND token = '8E911K9w1+lRJfhS2xnoQS6d42oIWSFxVDQcnbcl01Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}