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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21c0527f163e5cf9d6900e6c771ce81e9d4c8088b339b30b5107225ecd15def8' 
  AND token = 'BxNGS1cvZUFqcGSH0WvHY2EjYp7FBBJF0An3skm0xMM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}